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	angioimmunoblastic t-cell lymphoma

Disease ID	485
Disease	angioimmunoblastic t-cell lymphoma
Definition	A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.
Synonym	[m] angioimmunoblastic lymphadenopathy [m]angioimmunoblastic lymphadenopathy aild ailt angioblastic lymphadenopathy angioimmunoblastic lymphadenopathies angioimmunoblastic lymphadenopathy angioimmunoblastic lymphadenopathy (morphologic abnormality) angioimmunoblastic lymphadenopathy type t-cell lymphoma angioimmunoblastic lymphadenopathy with dysproteinaemia angioimmunoblastic lymphadenopathy with dysproteinemia angioimmunoblastic lymphadenopathy with dysproteinemia (aild) angioimmunoblastic lymphadenopathy with dysproteinemia (disorder) angioimmunoblastic lymphoma angioimmunoblastic t-cell lymphoma (disorder) angioimmunoblastic t-cell lymphoma (morphologic abnormality) immunoblastic lymphadenopathies immunoblastic lymphadenopathy immunoblastic lymphadenopathy [disease/finding] lymphadenopathies, angioimmunoblastic lymphadenopathies, immunoblastic lymphadenopathy, angioimmunoblastic lymphadenopathy, angioimmunoblastic, with dysproteinemia lymphadenopathy, immunoblastic peripheral t-cell lymphoma, aild (angioimmunoblastic lymphadenopathy with dysproteinaemia) peripheral t-cell lymphoma, aild (angioimmunoblastic lymphadenopathy with dysproteinemia)
Orphanet	ORPHANET:86886
ICD10	ICD10CM:C86.5
UMLS	C0020981
MeSH	D007119
SNOMED-CT	SNOMEDCT_US_2016_09_01:413537009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:29) C0024299 \| lymphoma \| 4 C0079731 \| b-cell lymphoma \| 3 C0024291 \| hemophagocytic lymphohistiocytosis \| 2 C0079744 \| diffuse large b-cell lymphoma \| 2 C0024299 \| lymphomas \| 2 C0079731 \| b-cell lymphomas \| 2 C0030807 \| pemphigus \| 1 C0409974 \| lupus erythematosus \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0031036 \| polyarteritis nodosa \| 1 C1522378 \| large granular lymphocytosis \| 1 C0023484 \| plasma cell leukemia \| 1 C0023418 \| leukemia \| 1 C0272286 \| immune thrombocytopenia \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0002871 \| anemia \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0034902 \| pure red cell aplasia \| 1 C0079731 \| b cell lymphoma \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C0242584 \| autoimmune thrombocytopenia \| 1 C0272126 \| evans syndrome \| 1 C0002878 \| hemolytic anemia \| 1 C0040034 \| thrombocytopenia \| 1 C0281963 \| red cell aplasia \| 1 C0035078 \| renal failure \| 1 C0026764 \| plasma cell myeloma \| 1 C0032285 \| pneumonia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 3418 \| IDH2 \| CTD_human 1788 \| DNMT3A \| CTD_human 54790 \| TET2 \| CTD_human 387 \| RHOA \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	485
Disease	angioimmunoblastic t-cell lymphoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:18) HP:0002716 \| Lymph node hyperplasia \| 4 HP:0012191 \| B-cell lymphoma \| 4 HP:0002665 \| Lymphoma \| 4 HP:0002664 \| Neoplasia \| 2 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001973 \| Autoimmune thrombocytopenia \| 1 HP:0001909 \| Leukemia \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0001903 \| Anemia \| 1 HP:0001873 \| Low platelet count \| 1 HP:0002958 \| Immune dysregulation \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0012410 \| Pure red cell aplasia \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0030150 \| Plasmacytosis \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0002090 \| Pneumonia \| 1

Disease ID	485
Disease	angioimmunoblastic t-cell lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C1962974 \| chylothorax C0079731 \| b-cell lymphomas C0037285 \| skin manifestations C0034902 \| pure red cell aplasia C0022660 \| acute renal failure C0014118 \| endocarditis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0079731 \| b-cell lymphomas \| 2 C0034902 \| pure red cell aplasia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs113488022	24689848	387	RHOA	umls:C0020981	BeFree	They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.	0.121357209	2014	BRAF	7	140753336	A	T,G,C
rs371896760	24689848	387	RHOA	umls:C0020981	BeFree	They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.	0.121357209	2014	ACAA1;MYD88	3	38138714	G	T
rs387907272	24689848	387	RHOA	umls:C0020981	BeFree	They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.	0.121357209	2014	MYD88	3	38141150	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	485
Disease	angioimmunoblastic t-cell lymphoma
Case	(Waiting for update.)

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